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A total of 92 cases were retrieved. The most common teratoma was ovarian (78.26%) followed by intracranial/intraspinal and sacrococcygeal in frequency of 7.61% each. Out of 92 cases, 89 were mature and benign, 2 cases were immature teratoma each in ovary and in sacrococcyx, and 1 case of teratocarcinoma in testis.
Background: Mature B-cell neoplasms (MBCNs) are a category of disorders with a broad range of clinical manifestations, pathologic features, and outcomes that share common characteristics. They originate from the B-cell lineage, are clonal, and have the immunophenotypic and genetic features of mature B-cells. Flow cytometry (FC) is a widely used method for diagnosing suspected lymphoproliferative disorders in patients with lymphocytosis, lymphadenopathy, and other lymphoproliferative disorders. Aim: To evaluate the role of FC in confirming the provisional morphologic diagnosis in patients with MBCNs. Materials and Methods: This is a retrospective; descriptive study conducted on 193 adult patients newly diagnosed with MBCNs; immunophenotypic findings of the patients were reviewed. The B lymphocytes were identified according to their Side-Scattered/CD19 distribution. Results: Chronic lymphocytic leukemia (CLL) was the most common subtype (127, 65.9%). Splenomegaly was noted more frequently in hairy cell leukemia variant cases (85.7%) and hairy cell leukemia cases (75%). The anemia at presentation was the least frequent in CLL (20%). The CD5+/CD23+ phenotype of CLL was seen in 114 cases (90%); negativity for FMC7 showed high sensitivity (93.7%) and sufficient specificity (60%) in the diagnosis of CLL. Conclusions: It is difficult to diagnose B-chronic lymphoproliferative disorders solely based on morphologic findings. Consequently, FC findings combined with clinical, hematologic, and morphologic features can confidently result in a precise diagnosis.
Chronic lymphoproliferative disorders (CLPDs) are a diverse group of leukemia and/or lymphomas characterized by the proliferation of mature B lymphoid cells in the peripheral blood (PB), bone marrow (BM), lymph nodes/spleen, and other lymphoid tissue.[1] B-cell neoplasms tend to mimic stages of natural B-cell differentiation, so they can be classified according to the normal stage to some degree. Nevertheless, some common B-cell neoplasms such as hairy cell leukemia do not appear to follow the typical B-cell differentiation level. Lineage heterogeneity or even more rarely, lineage plasticity can be found in some neoplasms. As a result, the neoplastic cell's natural counterpart cannot be used as the sole basis for classification.[2] Because it is difficult to diagnose hematologic disorders solely based on morphologic observations, so to make a reliable histologic diagnosis, alternative diagnostic modalities such as phenotyping via flow cytometry (FC) and immunohistochemistry are needed.[3] 041b061a72